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ITGB3 — TNFSF11

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Kim et al., Exp Cell Res 2003 (Bone Resorption) : Treatments of low doses of radicicol to RAW 264.7 cells that undergo osteoclastic differentiation in the presence of RANKL enhanced the RANKL induced gene expression of integrin beta3 without any effect on the expression of integrin alphav, which was constitutively high ... More importantly, modulation of ERK activity by the MEK inhibitor U0126 or the gene transduction of a constitutively active form of MEK resulted in a suppression and increment, respectively, of integrin beta3 induction by RANKL
Grigoriadis et al., Blood 2010 : Molecular analyses confirmed the expression of the osteoclast marker genes NFATc1, cathepsin K, and calcitonin receptor in a RANKL dependent manner, and confocal microscopy demonstrated the coexpression of the alphavbeta3 integrin , cathepsin K and F-actin rings characteristic of active osteoclasts