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FOXO1 — SREBF1

Text-mined interactions from Literome

Li et al., J Biol Chem 2006 : We conclude that insulin has dual effects on human CYP7A1 gene transcription ; physiological concentrations of insulin rapidly inhibit FoxO1 activity leading to stimulation of the human CYP7A1 gene, whereas prolonged insulin treatment induces SREBP-1c , which inhibits human CYP7A1 gene transcription
Kamei et al., Endocrinology 2008 : In addition, FOXO1 suppressed RXRalpha/LXRalpha mediated SREBP1c promoter activity in vitro ... In addition, FOXO1 suppressed RXRalpha/LXRalpha mediated SREBP1c promoter activity in vitro
Liu et al., FEBS Lett 2010 : FoxO1 represses LXRa mediated transcriptional activity of SREBP-1c promoter in HepG2 cells ... FoxO1 mediated suppression of SREBP-1c promoter activity could be partially alleviated by insulin
Deng et al., J Biol Chem 2012 : We examined the effects of FoxO1 on srebp1 gene expression in vivo and in vitro ... Similarly, in primary hepatocytes, CA-FoxO1 suppressed SREBP1-c expression and inhibited basal and insulin induced SREBP-1c promoter activity ... SREBP-1c gene expression is induced by the liver X receptor ( LXR ), but CA-FoxO1 did not block the activation of SREBP-1c by the LXR agonist TO9 ... CA-FoxO1 inhibited SREBP-1c by reducing the transactivational capacity of both Sp1 and SREBP-1c ... We conclude that FoxO1 inhibits SREBP-1c transcription via combined actions on multiple transcription factors and that this effect is exerted at least in part through reduced transcriptional activity of Sp1 and SREBP-1c and disrupted assembly of the transcriptional initiation complex on the SREBP-1c promoter