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GP6 — PARP1

Text-mined interactions from Literome

Richardson et al., Adv Exp Med Biol 1999 (Leukemia-Lymphoma, Adult T-Cell) : We conclude that PARP activation appears to be involved in apoptosis in certain leukaemic cell lines and that these effects are independent of lineage or p-glycoprotein
Larson et al., Blood 2003 : Because activation of Rap1, an abundant small guanosine triphosphatase ( GTPase ) in platelets, contributes to integrin alpha ( IIb ) beta ( 3 ) activation, we asked whether and how GPVI signaling activates Rap1 in platelets ... Using a reconstituted system in RBL-2H3 cells, we found that GPVI mediated Rap1 activation is dependent on FcRgamma but independent of another platelet collagen receptor, alpha ( 2 ) beta ( 1 ) ... Interestingly, GPVI mediated Rap1 activation in human platelets is largely dependent on adenosine diphosphate ( ADP ) signaling through the P2Y(12) and not the P2Y(1) receptor ... However, experiments with specific ADP receptor antagonists and platelets from knockout mice deficient in P2Y(1) or the P2Y(12) associated G-protein, Galphai ( 2 ), indicate that human and murine platelets also have a significant P2Y(12) independent component of GPVI mediated Rap1 activation
Canobbio et al., Blood 2009 : However, PI3Kbeta, but not PI3Kgamma, enzymatic activity was absolutely required for Akt phosphorylation, Rap1 activation , and platelet aggregation downstream of the immunoreceptor tyrosine based activation motif ( ITAM ) -bearing receptor glycoprotein VI (GPVI)
Gilio et al., J Biol Chem 2009 (Thrombosis) : Furthermore, PI3Kalpha/beta, but not PI3Kgamma, contributed to GPVI induced Rap1b activation and, surprisingly, also to Rap1b independent platelet activation via GPVI