Marchetti et al., Diabetologia 2012
(Diabetes Mellitus, Type 2) :
Finally, the N-terminal truncated form of HMGB1 was detected in the serum of type 2 diabetic patients, in whom DPP-IV inhibitors enhanced the levels of full-length HMGB1 ... DPP-IV cleaves HMGB1 and, via this mechanism, inhibits HMGB1 angiogenic activity
Schaper et al., Diabetologia 2012
:
Here we discuss the mechanisms underlying this impaired damage control in diabetes, with an emphasis on the proinflammatory cytokine high mobility group box 1 and the potential role of dipeptidyl peptidase IV inhibition in improving repair responses