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CCND1 — ERBB2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCND1 → ERBB2 (increases, CCND1 Activity) Sequeira et al., BMC cell biology 2009*
  Evidence: When compared to vector control MCF10A cells, cyclin D1 levels were significantly increased in Wt and to an even greater extent in CA-ErbB2 cells (Fig. 7C).
• OpenBEL Selventa BEL large corpus: CCND1 → ERBB2 (increases, CCND1 Activity)
  Evidence: The abundance of cyclin D1 is induced by a variety of oncogenic and growth factor signaling pathways, including activating mutations of Ras, Src, Rac, and erbB2 (HER-2/neu)
• OpenBEL Selventa BEL large corpus: CCND1 → ERBB2 (increases, CCND1 Activity) DeArmond et al., Oncogene 2003*
  Evidence: We determined that ErbB2 kinase contributed to aberrant cell cycle regulation in PDAC through the induction of cyclin D1 levels and the suppression of p21(Cip1) and p27(Kip1).

Text-mined interactions from Literome

Muraoka et al., Mol Cell Biol 2002 (Cell Transformation, Neoplastic...) : ErbB2/Neu destabilizes the cyclin dependent kinase (Cdk) inhibitor p27 and increases expression of cyclin D1
Casimiro et al., Cancer Res 2007 (Prostatic Intraepithelial Neoplasia...) : ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo ... Probasin promoter targeted expression of an activated ErbB-2 isoform induced cyclin D1 expression in the mouse prostate, commensurate with prostate intraepithelial neoplasia
Lindsay et al., Clinical and translational science 2008 (Breast Neoplasms) : ErbB2 induced cyclin D1 and cyclin D1 expression was suficient to induce Notch1 activity, and conversely, genetic deletion of Notch1 in mammary epithelial cells using foxed Notch ( Notch ( fl/fl ) ) mice demonstrated that cyclin D1 is induced by Notch1