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ANG — PLD1

Text-mined interactions from Literome

Parmentier et al., Hypertension 2001 : Angiotensin II (Ang II) activates cytosolic phospholipase A ( 2 ) ( cPLA(2) ) and phospholipase D ( PLD ) in rabbit vascular smooth muscle cells ( VSMCs )
Andresen et al., Hypertension 2001 (Hypertension) : Angiotensin II (Ang II) induced phospholipase D ( PLD ) activity is greater in aortic smooth muscle from spontaneously hypertensive rats ( SHR ) versus normotensive Wistar-Kyoto rats ( WKY ) ... The goals of the present study were to determine in SHR and WKY PGSMCs the following : ( 1 ) whether Ang II induces PLD activity ; ( 2 ) whether the effect of Ang II on PLD activity is greater in SHR ; ( 3 ) which PLD isoform is stimulated by Ang II ; ( 4 ) what signaling pathway mediates Ang II-induced PLD stimulation ; and ( 5 ) whether the signaling pathways mediating Ang II-induced PLD activity are different in SHR and WKY
Yoon et al., Biochem Biophys Res Commun 2003 : Interestingly, Ang1 increased PLD activities in a dose- and time dependent manner
Freeman et al., Am J Hypertens 1995 (Hypertension) : Ang- ( 2-8 ) caused a similar increase in PLD activity which was three times higher in SHR VSMC than in WKY controls ... In contrast, Ang- ( 1-7 ) did not affect PLD activity in either smooth muscle cell population ... We conclude that increased activation of PLD by Ang II in genetically induced hypertension may reflect an additional mechanism linking enhanced contractile responses to enhanced growth
Shinoda et al., Eur J Endocrinol 1997 : In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells
Jung et al., Biochem J 1998 : Ang II activated PLD with a dose dependence similar to that observed for aldosterone secretion, with slight increases in activity induced by 0.1 nM Ang II and maximal activation at 10 nM ... We also found that Ang II induced a sustained activation of PLD , but that the effect of carbachol, a stable analogue of acetylcholine, was transient ; PLD activity increased within 5 min of exposure to carbachol but then ceased by 15 min. Higher carbachol concentrations were also unable to sustain PLD activation
Ushio-Fukai et al., Mol Pharmacol 1999 : In cultured vascular smooth muscle cells ( VSMCs ), activation of phospholipase D ( PLD ) by angiotensin II (Ang II) represents a major source of sustained generation of second messengers