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IL1B — PLD1

Text-mined interactions from Literome

Chen et al., Diabetologia 1999 : Interleukin-1beta increased the expression of adenine nucleotide translocator-1, phospholipase D-1 and cytokine induced neutrophil chemoattractant-1 and decreased expression of the protein tyrosine phosphatase-like protein IA-2
Tong et al., J Mol Neurosci 1999 : However, despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D ( PLD ) and synthesis of phosphatidylethanol ( PEt ) in these cells, PLD activity was not affected by IL-1beta
Chen et al., Endocrinology 2000 : Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells ... NG-methyl-L-arginine ( LMA ), a blocker of the inducible form of nitric oxide synthase ( iNOS ), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta induced decrease in PLD1a expression is NO-mediated ... IL-1beta induced an early ( 2-6 h ) and sustained ( 16-24 h ) increase in PLD1a mRNA expression in insulin producing RINm5F cells ... In conclusion, we have shown that the cytokine IL-1beta regulates PLD1 expression in primary and clonal beta-cells
Park et al., Mol Pharmacol 2002 : The results of this study indicate that in human amnion cells, IL-1 beta might activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression
Sethu et al., J Immunol 2008 (Calcium Signaling...) : Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that PLD1 is required for TNF-alpha induced production of several important cytokines, such as IL-1beta , IL-5, IL-6, and IL-13, in human monocytes