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Text-mined interactions from Literome
Wise et al., Arch Oral Biol 2000
:
By reverse transcription-polymerase chain reaction, it was demonstrated that
PTHrP enhanced
MCP-1 expression in a concentration dependent fashion, with 50 ng PTHrP/ml inducing maximal expression of either MCP-1 or CSF-1 ... Immunoblotting revealed that
PTHrP also
enhanced secretion of
MCP-1 by the follicle cells
MartÃn-Ventura et al., Stroke 2003
(Arteriosclerosis...) :
Moreover, in cultured vascular smooth muscle cells ( VSMC ),
PTHrP ( 1-36 )
increased MCP-1 mRNA ( 3-fold at 6 hours ) and
MCP-1 protein ( 2.5-fold at 24 hours )
Ortega et al., J Am Soc Nephrol 2006
(Fibrosis) :
PTHrP ( 1-36 ) also
stimulated monocyte chemoattractant protein-1 expression in tubuloepithelial cells, as well as type-1 procollagen gene expression and fibronectin ( mRNA levels and protein secretion ) in these cells and renal fibroblastic cells
Lu et al., Int J Cancer 2007
(Disease Progression...) :
PTHrP induced
MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro ... Accordingly, we first determined the
effect of
PTHrP on
MCP-1 expression by bone cells and PCa cells ... To further determine the mechanisms of
PTHrP induced
MCP-1 transcription, analysis of the MCP-1 promoter was performed ...
MCP-1 promoter activity was
induced by
PTHrP ... Both C/EBPbeta and NF-kappaB binding elements are required for
PTHrP induced
MCP-1 transcription ... We conclude that
PTHrP induced
MCP-1 production by HBME and hFOB cells promotes osteoclast differentiation in vitro and such induction may play a critical role in PCa development in the bone microenvironment