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AURKA — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
AURKA
—
TP53
Chen et al., EMBO J 2002*
-
IRef Bind_translation Interaction:
AURKA
—
TP53
(two hybrid)
Chen et al., EMBO J 2002*
-
IRef Bind_translation Interaction:
AURKA
—
TP53
(affinity chromatography technology)
Chen et al., EMBO J 2002*
-
IRef Bind_translation Interaction:
AURKA
—
TP53
(coimmunoprecipitation)
Chen et al., EMBO J 2002*
-
IRef Biogrid Interaction:
AURKA
—
TP53
(direct interaction, two hybrid)
Chen et al., EMBO J 2002*
-
IRef Biogrid Interaction:
AURKA
—
TP53
(physical association, affinity chromatography technology)
Chen et al., EMBO J 2002*
-
IRef Biogrid Interaction:
AURKA
—
TP53
(direct interaction, pull down)
Chen et al., EMBO J 2002*
-
IRef Biogrid Interaction:
AURKA
—
TP53
(direct interaction, pull down)
Katayama et al., Nat Genet 2004*
-
IRef Biogrid Interaction:
AURKA
—
TP53
(physical association, affinity chromatography technology)
Katayama et al., Nat Genet 2004*
-
IRef Hprd Interaction:
TP53
—
AURKA
(in vitro)
Chen et al., EMBO J 2002*
-
IRef Hprd Interaction:
TP53
—
AURKA
(in vivo)
Chen et al., EMBO J 2002*
-
IRef Hprd Interaction:
TP53
—
AURKA
(two hybrid)
Chen et al., EMBO J 2002*
-
IRef Ophid Interaction:
AURKA
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chen et al., EMBO J 2002
:
The suppression of STK15 oncogenic activity by p53 might be explained in part by the finding that
p53 inhibited
STK15 kinase activity via direct interaction with the latter 's Aurora box
Katayama et al., Nat Genet 2004
:
p53 is not degraded in the
presence of inactive
aurora kinase A or ubiquitination-defective Mdm2 ... We conclude that aurora kinase A is a key regulatory component of the p53 pathway and that overexpression of
aurora kinase A leads to increased degradation of
p53 , causing downregulation of checkpoint-response pathways and facilitating oncogenic transformation of cells
Lee et al., Cell stem cell 2012
:
By integrating global gene expression and computational analyses, we discovered that loss of
Aurka leads to upregulated
p53 activity that triggers ESC differentiation