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BMP7 — PRG2
Text-mined interactions from Literome
Loeser et al., J Rheumatol 2003
(Osteoarthritis) :
In contrast, compared to controls,
OP-1 at 100 ng/ml
stimulated a 3-fold increase in matrix
proteoglycan at day 21 of culture
Zhang et al., Am J Phys Med Rehabil 2004
:
OP-1 stimulates
proteoglycan accumulation by bovine IVD cells isolated from all three zones of the bovine IVDs
Zhang et al., Am J Phys Med Rehabil 2005
:
Low-dose interleukin-1 partially counteracts
osteogenic protein-1 induced
proteoglycan synthesis by adult bovine intervertebral disk cells
Flechtenmacher et al., Arthritis Rheum 1996
:
To study the
effects of recombinant human
osteogenic protein-1 ( rHuOP-1 ; bone morphogenetic protein-7 ) on
proteoglycan and collagen synthesis by human articular chondrocytes
Lietman et al., J Bone Joint Surg Am 1997
:
Stimulation of
proteoglycan synthesis in explants of porcine articular cartilage by recombinant
osteogenic protein-1 ( bone morphogenetic protein-7 ) ... The
stimulation of
proteoglycan synthesis by
osteogenic protein-1 ( bone morphogenetic protein-7 ) in explants of cartilage maintained in chemically defined serum-free medium implies that recombinant osteogenic protein-1 may play a role in the maintenance of a steady-state concentration of proteoglycans in articular cartilage, a desirable prerequisite for optimum repair of cartilage
Wu et al., J Cell Biochem 1997
:
Alone,
OP-1 caused approximately 2-fold increase in
proteoglycan synthesis into both the medium and the cell : matrix layer
Huch et al., Arthritis Rheum 1997
:
Effects of recombinant human
osteogenic protein 1 on the production of
proteoglycan , prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1beta