Gene interactions and pathways from curated databases and text-mining

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HGF — MAP2K1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAP2K1 → HGF (increases) Ma et al., Br J Cancer 2007*
    Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...

Text-mined interactions from Literome

Karihaloo et al., J Biol Chem 2001 : Similarly, HGF dependent , but not EGF dependent, branching morphogenesis was more greatly inhibited by the MKK1 inhibitor
Taniguchi et al., Mol Reprod Dev 2004 (MAP Kinase Signaling System) : Here, we showed that HGF activated the distinct phosphorylation of Raf-1, MEK1/2 , and ERK1/2, but did not induce phosphorylation of Akt
Rush et al., Exp Cell Res 2007 (MAP Kinase Signaling System) : Stimulation of HBMECs by HGF led to rapid activation of ERK1/2, phosphorylation of Raf-1 at Ser ( 338 ) and Tyr ( 340/341 ) and MEK1/2 at Ser ( 222 )