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HGF — MAP2K1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAP2K1
→
HGF
(increases)
Ma et al., Br J Cancer 2007*
Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...
Text-mined interactions from Literome
Karihaloo et al., J Biol Chem 2001
:
Similarly,
HGF dependent , but not EGF dependent, branching morphogenesis was more greatly inhibited by the
MKK1 inhibitor
Taniguchi et al., Mol Reprod Dev 2004
(MAP Kinase Signaling System) :
Here, we showed that
HGF activated the distinct phosphorylation of Raf-1,
MEK1/2 , and ERK1/2, but did not induce phosphorylation of Akt
Rush et al., Exp Cell Res 2007
(MAP Kinase Signaling System) :
Stimulation of HBMECs by
HGF led to rapid activation of ERK1/2, phosphorylation of Raf-1 at Ser ( 338 ) and Tyr ( 340/341 ) and
MEK1/2 at Ser ( 222 )