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HGF — MMP2

Text-mined interactions from Literome

Hamasuna et al., Int J Cancer 1999 (Brain Neoplasms...) : Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor ( HGF/SF ) in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP ... We investigated the effect of HGF/SF on matrix metalloproteinase-2 (MMP-2) , membrane type 1 matrix metalloproteinase ( MT1-MMP ) and tissue inhibitors of metalloproteinases ( TIMPs ), expressions of c-Met/HGF receptor positive human glioblastoma cells ... The stimulatory effect of HGF/SF on MMP-2 expression did not occur in the presence of herbimycin A, a protein tyrosine kinase inhibitor ... MT1 -MMP , a cell-surface activator of proMMP-2, was also up-regulated by HGF/SF in a dose dependent manner ... HGF/SF also stimulated MMP-2 expression of other glioblastoma cell lines
Hanzawa et al., Carcinogenesis 2000 (Carcinoma, Squamous Cell...) : Here we examined the effect of HGF on E1AF and MMP gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3
Wang et al., Biochem Biophys Res Commun 2000 (MAP Kinase Signaling System) : Hepatocyte growth factor enhances MMP activity in human endothelial cells ... We showed that SF/HGF enhanced MT1-MMP synthesis and induced MMP-2 activation in two human EC lines : dermal microvessel EC and coronary arterial EC
Bennett et al., Eur J Oral Sci 2000 (Carcinoma, Squamous Cell...) : Metalloproteinase expression in normal and malignant oral keratinocytes : stimulation of MMP-2 and -9 by scatter factor
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF) , monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6, though the mechanisms were not clear
Daniels et al., Invest Ophthalmol Vis Sci 2003 : HCEC migration ( P < 0.05 ) and MMP-2 and -9 released into the medium increased in response to HGF in a dose dependent manner up to 20 ng/mL
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6, HGF , and 12-O-tetradecanoylphorbol 13-acetate
Park et al., Int J Gynecol Cancer 2003 (Adenocarcinoma...) : Zymographic analysis of MMPs showed that activation of MMP-2 and -9 was enhanced by HGF ... The effect of HGF on the invasiveness of 3D cocultured endometrial cancer cells and stromal cells appears to be due to induction of MMP-9 mRNA expression in stromal cells and /or increased activation of MMP-2 and MMP-9 by proteolytic digestion
Fujiuchi et al., Oncol Rep 2003 (Neoplasm Invasiveness...) : Furthermore, HGF also increased the production of MMP-1 and -9, MT1-MMP , u-PA and uPAR of these cells
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Mizuno et al., FASEB J 2005 (Pulmonary Fibrosis) : For the myofibroblast-like cells, HGF increased activities of MMP-2/-9 , predominant enzymes for breakdown of fibronectin ( FN )
Li et al., World J Gastroenterol 2005 (Colorectal Neoplasms...) : HGF promoted Caco-2 migration mainly by p42/p44MAPK pathway ; HGF/SF stimulated the expression of MMP-2 , MMP-9 in Caco-2 and enabled tumoral cells to damage the ECM and reach the distant organ and develop metastasis ; HGF played the function of promoted-invasion and promoted-metastasis, in which cellular selection was possible ... Compared with controls, MMP-2 and MMP-9 mRNA expressions were up-regulated by HGF ( 0.997+/-0.011 vs 1.207+/-0.003, t = 35.002,P = 0.001 < 0.01 ; 0.387+/-0.128 vs 0.971+/-0.147, t = 106.036, P = 0.0000 < 0.01, respectively ) ; compared with controls, TIMP-1, TIMP-2 mRNA expressions were increased by PD98059 ( 1.344+/-0.007 vs 1.905+/-0.049, t = 17.541, P = 0.003 < 0.01 ; 1.286+/-0.020 vs 1.887+/-0.022,t = 24.623, P = 0.002 < 0.01, respectively )
Ide et al., Int J Cancer 2006 (Neoplasm Invasiveness...) : Conversely, the elevated cancer invasion, MMP activity and c-Met phosphorylation of PK8 cells were reduced by the removal of HGF from hypoxic conditioned medium
Yamada et al., Int J Biochem Cell Biol 2008 : Experiments reported herein provide evidence that MMP2 may be involved in the NO-dependent release of HGF in vitro ... Therefore, results from these experiments provide evidence that NO-activated MMP2 may cause release of HGF from the extracellular matrix of satellite cells and contribute to satellite cell activation
Ohno et al., Laryngoscope 2009 : HGF induced the upregulation of MMP-2 , -9, and HAS-3, and downregulated the expression of procollagen type I. Histologically, aged vocal folds treated with HGF revealed decreased collagen deposition, and increased deposition of HA, compared to sham treated vocal folds
Ozen et al., PloS one 2012 (Carcinoma, Hepatocellular...) : HGF induced MMP-2 and MMP-9 activation, and MT1-MMP expression, also were inhibited by heparin
Tsou et al., PloS one 2013 (Chondrosarcoma...) : HGF treatment resulted in activation of the phosphatidylinositol 3'-kinase (PI3K)/Akt/PKCd/NF-?B pathway, and HGF induced expression of MMP-2 and cell migration was inhibited by specific inhibitors or siRNA-knockdown of PI3K, Akt, PKCd, and NF-?B cascades
Li et al., Clin Exp Metastasis 1998 (Adenocarcinoma...) : In the presence of HGF , the 72 kDa type IV collagenase ( MMP-2 ) activity of GB-h3 and u-PA activities of GB-d1, GB-h3 and GB-d2 were enhanced
Aparicio et al., C R Seances Soc Biol Fil 1998 (Colonic Neoplasms...) : After 24 or 48 h of culture in medium supplemented with HGF, transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate, MMP production by DHD/K12 cells was stimulated by HGF and TGF-alpha and inhibited by sodium butyrate