◀ Back to HGF

DGKA — HGF

Text-mined interactions from Literome

Baldanzi et al., Oncogene 2008 : Here, we demonstrate that both hepatocytes growth factor (HGF) stimulation and v-Src transformation induce tyrosine phosphorylation of Dgk-alpha on Y335, through a mechanism requiring its proline-rich C-terminal sequence
Chianale et al., Mol Biol Cell 2007 : We previously showed that hepatocyte growth factor (HGF) , vascular endothelial growth factor, and anaplastic lymphoma kinase activate Dgkalpha in endothelial and leukemia cells through a Src mediated mechanism and that activation of Dgkalpha is required for chemotactic, proliferative, and angiogenic signaling in vitro ... We report that specific inhibition of Dgkalpha , obtained either pharmacologically by R59949 treatment, or by expression of Dgkalpha dominant negative mutant, or by small interfering RNA mediated down-regulation of endogenous Dgkalpha, impairs 1 ) HGF- and v-Src induced cell scatter and migration, without affecting the loss of intercellular adhesions ; 2 ) HGF induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling ; and 3 ) HGF induced Rac activation and membrane targeting