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BMP2 — PIK3R1

Text-mined interactions from Literome

Ghosh-Choudhury et al., J Biol Chem 2003 : Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2) induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells
Ghosh-Choudhury et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Expression of dominant negative PI3K and PTEN, an inhibitor of PI3K signaling, significantly attenuated lovastatin induced transcription of BMP-2
Lee et al., Int Immunopharmacol 2008 : Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen activated protein ( MAP ) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K
Fong et al., J Cell Physiol 2008 (Chondrosarcoma) : Taken together, these results suggest that the BMP-2 acts through PI3K/Akt , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... Selective inhibition of PI3K/Akt suppressed the NF-kappaB induced BMP-2 promoter activity
Mandal et al., Endocrinology 2009 : Inhibition of PI3K/Akt signaling blocked the binding of Smads 1/5 to the CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Liu et al., Biochem Biophys Res Commun 2013 : Furthermore, in the presence of exogenous BMP-2 , PI3K and Akt inhibitors blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ueki et al., Glia 2013 : Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation