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APCS — CD8A

Text-mined interactions from Literome

Donnini et al., Exp Gerontol 2002 : APCs from old mice induced similar lymphocyte proliferative responses but lower lymphocyte cytotoxicity and a reduced number of CD8 ( + ) T cells producing IFNgamma in comparison with APCs from young animals
Gnjatic et al., J Immunol 2003 : To address the antigenicity of long peptides, we analyzed two synthetic 30-mer peptides from NY-ESO-1, polypeptides 80-109 and 145-174, for their capacity to be processed by APCs and to stimulate CD8 ( + ) T cells
Sharma et al., Cancer Immunol Immunother 2008 (Mammary Neoplasms, Experimental) : Analysis of the immune responses in the old indicated that CpG-ODN but not Poly-I:C induces : a pro-inflammatory Th1 type response ; accumulation and activation of CD4+, CD8+ T and, NK cell responses ; activation of APCs ; and reduction in the number of Tregs
Guan et al., J Neuroimmunol 2007 (Disease Models, Animal...) : These APCs treated with M-CSF+autoantigen peptide significantly suppressed antigen-specific T cell proliferation, induced regulatory CD4 ( + ) and CD8 ( + ) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis ( EAE )
Lee et al., J Immunol 2009 : Furthermore, HBcAg-specific CD4 ( + ) and CD8 ( + ) T cell priming with DNA encoding HBcAg does not require B cell APCs
Vanden Bush et al., J Immunol 2009 : CD40- or TLR7 stimulated B cell APCs induced similar CD8 ( + ) T cell responses, but costimulation through the BCR and TLR7 produced a more effective Bvac as measured by T cell stimulation and the protection of mice from an infectious pathogen
Mauri et al., J Immunol 1995 : Our data implicate that activated T-APCs preferentially induce a cytotoxic, CD8+ and CD4+ T cell response