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CDK2 — CDK6
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDK6
—
CDK2
(association, biochemical)
Cheng et al., J Biol Chem 2000*
-
Gene Ontology Complexes cyclin-dependent protein kinase holoenzyme complex:
cyclin-dependent protein kinase holoenzyme complex complex (CDK2-CCND2-CDKN1A-CDK6)
Ruas et al., Mol Cell Biol 2007*, Wang et al., Cell Struct Funct 2008*, Meyerson et al., Mol Cell Biol 1994*, Reardon et al., Proc Natl Acad Sci U S A 1996
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IRef Ophid Interaction:
CDK6
—
CDK2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Tanguay et al., J Immunol 1999
:
By contrast, inhibition of
Cdk4/6 activities is not
due to suppression of Cdk4/6 or cyclins D2/D3 expression or inhibition of
Cdk activating kinase activity
Chae et al., Laryngoscope 2000
(Cholesteatoma, Middle Ear) :
Cyclin-CDK complexes are in turn
regulated by the
cyclin dependent kinase inhibitors ( CDKIs ), which generally inhibit cell cycle progression
Okahashi et al., J Cell Biochem 2001
:
In this study, we found that stimulation of M-BMMPhis with sODF/RANKL induced a transient expression of
cyclin dependent kinase inhibitors (
CDK inhibitors ) p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) by 24 h
You et al., Genes Dev 2002
:
CDK2 activity is
regulated by phosphorylation/dephosphorylation, subcellular localization, cyclin levels, and
cyclin dependent kinase inhibitors ( CKIs )
Rylski et al., Mol Cell Biol 2003
:
GATA-1 inhibited expression of
cyclin dependent kinase (Cdk) 6 and cyclin D2 and
induced the
Cdk inhibitors p18(INK4C) and p27 ( Kip1 ) with associated inactivation of all G ( 1 ) Cdks
Eluère et al., J Cell Sci 2007
:
Orderly progression through the eukaryotic cell cycle is a complex process involving both regulation of
cyclin dependent kinase activity and
control of specific
substrate-Cdk interactions
Lee et al., Carcinogenesis 2007
:
The protein and mRNA levels of
CDK inhibitors (
cyclin dependent kinase inhibitors ), such as p21 ( CIP1/WAF1 ) and p27 ( KIP1 ), were gradually increased after acteoside treatment in a time dependent manner
Kwon et al., Cancer Lett 2010
(Adenocarcinoma...) :
Induction of G1 arrest by widdrol was correlated with induction of Chk2, p53 phosphorylation and
CDK inhibitor p21 expression as well as
inhibition of cyclin E,
cyclin dependent kinase ( CDK2 ) and retinoblastoma protein ( pRB )
Lee et al., Exp Mol Med 2009
(Neoplasms) :
Tight
CDK regulation
involves cyclin dependent kinase inhibitors ( CKIs ) which ensure the correct timing of CDK activation in different phases of the cell cycle
Molenaar et al., Genes Chromosomes Cancer 2012
(Chromosome Aberrations...) :
The activity of the
cyclin-CDK complexes is
regulated by
cyclin dependent kinase inhibitors ( CDKIs ) and multiple signal transduction routes that converge on the cell cycle
Mandal et al., Oncogene 1998
:
Interferon-induces expression of cyclin dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent
activation of
cyclin dependent kinase by
CDK activating kinase (CAK)