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HSP90AA1 — KIT

Text-mined interactions from Literome

Li et al., Clin Cancer Res 2008 (Gastrointestinal Stromal Tumors) : An Hsp90 inhibitor, 17-AAG, can attenuate KIT activation and proliferation of gastrointestinal stromal tumor cell lines
Dickson et al., Ann Oncol 2013 (Gastrointestinal Stromal Tumors) : Background HSP90 inhibition leads to proteosomal degradation of activated KIT and has in vitro activity against gastrointestinal stromal tumors ( GIST )
Hsueh et al., Autophagy 2013 (Gastrointestinal Stromal Tumors) : Therefore, the results not only highlight the potential application of AUY922 for the treatment of KIT expressing GISTs, but also provide the first evidence for the involvement of autophagy in endogenous and HSP90AA1 inhibitor induced KIT degradation