Gene interactions and pathways from curated databases and text-mining

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IL13 — TNC

Text-mined interactions from Literome

Jinnin et al., J Invest Dermatol 2006 : Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways
Maqbool et al., Matrix Biol 2013 : ECM-regulatory matricellular proteins are synthesized by several myocardial cell types including CF. We investigated the effects of pro-inflammatory cytokines on matricellular protein expression in cultured human CF. cDNA array analysis of matricellular proteins revealed that interleukin-1a ( IL-1a, 10ng/ml, 6h ) down-regulated connective tissue growth factor ( CTGF/CCN2 ) mRNA by 80 % and up-regulated tenascin-C (TNC) mRNA levels by 10-fold in human CF, without affecting expression of thrombospondins 1-3, osteonectin or osteopontin