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IRF6 — STAT3

Text-mined interactions from Literome

Bode et al., FEBS Lett 1999 : LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6 induced activation of STAT3 in macrophages
Harré et al., J Appl Physiol 2002 (Fever) : Selected contribution : role of IL-6 in LPS induced nuclear STAT3 translocation in sensory circumventricular organs during fever in rats ... Nuclear STAT3 translocation in response to LPS was observed within the vascular organ of the lamina terminalis ( OVLT ) and the subfornical organ ( SFO ) 2 h after LPS treatment
Bode et al., J Immunol 2003 : Recently, it has been demonstrated that TNF-alpha and LPS induce the expression of suppressor of cytokine signaling 3 ( SOCS3 ) and inhibit IL-6 induced STAT3 activation in macrophages
Nishiki et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : G-CSF mediated inhibition of LPS induced TNF-alpha production as well as G-CSF induced STAT3 phosphorylation and suppressor of cytokine signaling 3 mRNA expression were prevented by pretreatment of monocytes with AG-490, an inhibitor of Janus kinase 2 ... G-CSF induced, but not IL-10 induced, STAT3 phosphorylation was attenuated in the presence of LPS
Carl et al., J Leukoc Biol 2004 : Role of endogenous IL-10 in LPS induced STAT3 activation and IL-1 receptor antagonist gene expression ... Western blot analysis of phosphorylated STAT3 from wild-type and IL-10-/- BMDM and IL-10 neutralization experiments demonstrated a role for endogenously produced IL-10 in the LPS induced STAT3 activity
Hoentjen et al., Blood 2005 : Chromatin immunoprecipitation demonstrated enhanced NF-kappaB ( cRel, RelA ) binding to the IL-12p40 promoter in IL-10 ( -/- ) but not WT BMDCs. Interestingly, LPS induced STAT3 phosphorylation in WT but not IL-10 ( -/- ) BMDCs, a process blocked by IL-10 receptor blocking antibody
Hosoi et al., Brain Res 2004 : LPS induced STAT3 phosphorylation was peaked at 2-4 h and declined there after ... Interestingly, we observed no effect of dexamethasone on LPS induced STAT3 phosphorylation in the hypothalamus
Huang et al., J Biol Chem 2004 (Arteriosclerosis) : Splenocytes from IRAK1-deficient mice fail to exhibit LPS induced Stat3 serine phosphorylation and IL-10 gene expression yet still maintain normal IL-1beta gene expression upon LPS challenge
Rummel et al., J Comp Neurol 2005 (Translocation, Genetic) : Here we show in the guinea pig a time dependent marked LPS induced STAT3 activation within astrocytes and endothelial cells of the CVOs, within astrocytes located in brain structures with a functional BBB and within the brain endothelium of the entire brain
Liu et al., Zhonghua Shao Shang Za Zhi 2005 : In addition, the cells were divided into normal control, LPS stimulation, JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups ... LPS could activate JAK2, STAT1 and STAT3 within 2 hours, especially the activation of STAT3 appeared more quickly, peaking at 10 minutes after LPS stimulation ( 7.47 +/- 0.56 )
Leng et al., Exp Hematol 2006 (Graft vs Host Disease...) : Concomitantly, SAHA treatment inhibited phosphorylation of STAT1 and STAT3 in response to LPS and alloactivation in vitro
Prêle et al., Immunology 2006 : SOCS3 over-expression had no effect on TNF-alpha mRNA levels induced by LPS or LPS plus IL-10, or on IL-10 phosphorylation of STAT3 , STAT1 and ERK1/2
Staples et al., J Immunol 2007 : Finally, we show that overexpression of a dominant negative Stat3 protein will prevent IL-10 induction, but not LPS induction, of IL-10 mRNA
Qin et al., J Immunol 2007 (MAP Kinase Signaling System) : These results indicate that LPS induced MAPK activation, the production of endogenous IL-10, and STAT-3 activation play critical roles in SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Huang et al., J Clin Invest 2007 (Inflammation...) : Enforced expression of STAT1, IRF-1 , or GATA-1 enhanced phosphorylation of STAT1, STAT3 , and STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Chen et al., Dig Dis Sci 2009 : Anti-IL-6 neutralizing antibody inhibited LPS induced proliferation of cholangiocytes and decreased levels of IL-6 and STAT3
Park et al., Cytokine 2008 : Furthermore, we found that LPS induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine
Schaefer et al., Mol Immunol 2009 : In gelshift analysis this Stat motif did bind LPS induced Stat3 and with IFNgamma treatment it did, in addition, bind Stat1
Samavati et al., Mol Immunol 2009 (Inflammation) : A newly developed STAT3 specific inhibitor ( stattic ) blocked LPS mediated STAT3 tyrosine phosphorylation and led to inhibition of LPS mediated IL-1beta and IL-6 production but not TNF-alpha production
Wang et al., Lab Invest 2010 (Disease Models, Animal...) : Importantly, LPS/GalN induced hepatic Stat3 survival signaling was impaired and early activation of Jak2 was delayed in PXR-null mice
Peña et al., J Mol Med (Berl) 2010 (Sepsis) : JAK2 inhibition specifically prevents LPS induced STAT3 tyrosine phosphorylation without affecting serine phosphorylation in macrophages
Nhu et al., Innate Immun 2012 : In contrast, PAR 2-/- macrophages exhibited diminished LPS induced IL-10 mRNA and protein expression and downstream STAT3 activation, but increased KC mRNA and protein
Min et al., Int Immunopharmacol 2011 (Inflammation) : Withaferin A had no effect on LPS induced Akt and ERK phosphorylation, but phosphorylation of p38 and JNK was slightly decreased by withaferin A. Withaferin A significantly inhibited LPS induced STAT1 and STAT3 phosphorylation in a dose dependent manner
Ehlting et al., J Biol Chem 2011 : By analyzing the role of MAPK activated protein kinase (MK) 2 and MK3 for LPS induced STAT3 activation in macrophages, the present study provides evidence that MK2 is crucial for STAT3 activation in response to LPS because it prevents MK3 from impeding IFNß gene expression ... In summary, evidence is provided that MK2 regulates LPS induced IFNß expression and downstream STAT3 activation as it restrains MK3 from mediating negative regulatory effects on NF?B- and interferon regulatory factor 3-dependent LPS signaling
Chen et al., BMC immunology 2011 : STAT3 activation by LPS with or without Shc blockade was totally abolished by SU6656, a selective Src family kinases inhibitor, underscoring the critical role of Src mediated activation
Lee et al., Journal of neuroinflammation 2011 (Inflammation) : Moreover, studies using signal transducer and activator of transcription 3 ( STAT3 ) siRNA and a pharmacological inhibitor showed that 2,4-bis ( p-hydroxyphenyl ) -2-butenal inhibits LPS induced activation of STAT3
Burton et al., Brain Behav Immun 2012 (Infection) : The LPS induced increase in STAT3 activity was ablated in aged IL-6 ( -/- ) mice, suggesting IL-6 is a key driver of STAT3 activity in the aged brain ... Importantly, the LPS induced increases in both IL-6 and STAT3 activity in the hippocampus were inhibited by sgp130
Yu et al., Inflammation 2012 (Inflammation) : In addition, pyranocoumarins suppressed LPS induced STAT3 tyrosine phosphorylation
Park et al., PloS one 2011 : However, capric acid inhibited LPS induced phosphorylation of Ser ( 727 ) in STAT3
Paris et al., Eur J Pharmacol 2013 (Alzheimer Disease...) : Our data show that anatabine prevents STAT3 and NF?B phosphorylation induced by lipopolysaccharide (LPS) or TNF-a in SH-SY5Y, HEK293, human microglia and human blood mononuclear cells ... We observed that anatabine reduces pro-inflammatory cytokine production ( IL-6, IL-1ß and TNF-a ) in the plasma, kidney and spleen of the animals following the injection of LPS and concomitantly opposes STAT3 phosphorylation induced by LPS in the spleen and kidney
Gui et al., Mediators Inflamm 2013 (Sepsis) : Further studies showed that GW405833 inhibits LPS induced phosphorylation of ERK1/2 and STAT3 and blocks I ? B a degradation and NF- ? B p65 nuclear translocation in macrophages
Takeda et al., J Endocrinol 1998 : The synergism was studied on the two other IL-6 response elements, the junB promoter ( JRE-IL-6 ) and the interferon regulatory factor-1 (IRF-1) promoter ( IRF-GAS ) which could be activated by STAT3