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Edwin et al., J Biol Chem 2006
:
By using PTEN null primary mouse embryonic fibroblasts and their isogenic controls as well as small interfering RNA against PTEN, we demonstrated that PTEN is necessary for hSPRY2 to inhibit Akt activation by epidermal growth factor as well as cell proliferation
Saxena et al., Antioxid Redox Signal 2013
(Colonic Neoplasms...) :
Inhibition of AR also prevented the epidermal growth factor induced phosphorylation of phosphatidylinositol 3-kinase (PI3K), serine/threonine kinase ( AKT ), c-Jun, c-Fos, PTEN , and FOXO3a, and deoxyribonucleic acid ( DNA ) -binding activity of AP-1