Richard et al., J Biol Chem 2000
:
More interestingly, Angiotensin II (Ang II) , thrombin, platelet derived growth factor, and other hormones can also increase HIF-1alpha in VSMC to levels that are substantially more elevated than the hypoxic treatment ... HIF-1alpha induced by Ang II is located in the nucleus, binds to the hypoxic response element, and is transcriptionally active
Chen et al., Ann N Y Acad Sci 2005
:
In this study, we show that angiotensin II (Ang II) increased HIF-1alpha protein levels in a time- and dose dependent manner under normoxic conditions