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AKT3 — MUC1

Text-mined interactions from Literome

Lee et al., Am J Physiol Lung Cell Mol Physiol 2006 (Carcinoma, Mucoepidermoid...) : PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke induced mucin production, with the upregulation of PTEN signaling and downregulation of Akt expression
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation) : Our results showed 1 ) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail ( CT ) as well as Akt phosphorylation, 2 ) MUC1 induced Akt phosphorylation required the presence of Tyr ( 20 ) within the PI3K binding motif of the MUC1 CT, and 3 ) mutation of Tyr ( 20 ) or pharmacological inhibition of PI3K activation failed to block MUC1 induced suppression of TLR5 signaling
Raina et al., Mol Cancer Ther 2011 (Carcinoma, Non-Small-Cell Lung) : We show that inhibition of MUC1-C with cell penetrating peptides blocks this interaction with PI3K p85 and suppresses constitutive phosphorylation of Akt and its downstream effector, mTOR
Xu et al., PloS one 2012 : Suppression of MUC1 expression resulted in EGFR destabilization and inhibition of the BPDE induced activation of Akt and ERK and increase of cytotoxicity
Jin et al., Oncogene 2013 : Compared with MCF-10A cells, constitutive overexpression of MUC1-C in breast cancer cells was unaffected by EGF stimulation, but was blocked by inhibiting PI3K?AKT signaling
Kharbanda et al., Mol Cancer Res 2013 : In contrast, overexpression of MUC1-C in tamoxifen-sensitive MCF-7 breast cancer cells resulted in upregulation of p-AKT and tamoxifen resistance