Nellist et al., J Biol Chem 2002
:
Although it has been shown that hamartin and tuberin form a complex and mediate phosphoinositide 3-kinase/Akt dependent phosphorylation of the ribosomal protein S6 , it is not yet clear how inactivation of either protein leads to tuberous sclerosis
Saba et al., J Investig Med 2012
(Acquired Immunodeficiency Syndrome...) :
Protein kinase C-beta-selective inhibition was observed not to affect AKT phosphorylation but to induce a rapid and sustained reduction in the phosphorylation of glycogen synthase kinase-3 beta, ribosomal protein S6 , and mammalian target of rapamycin in sensitive cell lines
Zhu et al., Mol Endocrinol 2013
:
One potential mechanism is PI3K- and Akt mediated activation of mechanistic target of rapamycin (mTOR) and ribosomal protein S6 kinase (S6K) , which may impair insulin mediated activation of insulin receptor substrate (IRS)1/2 via inhibitory serine phosphorylation or proteasomal degradation