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ANGPT2 — HGF

Text-mined interactions from Literome

Yasuda et al., Hypertension 1999 (Heart Failure...) : We hypothesized that HGF production is impaired as the result of increased Ang II in patients with congestive heart failure, and that if so, the impaired production should be restored with angiotensin converting enzyme inhibitors ( ACE-I )
Matsumoto et al., Hypertension 1999 (Hypertension, Renal) : We next examined the effects of Ang II blockade on renal HGF expression in SHR-SP. Renal HGF mRNA was markedly decreased in SHR-SP compared with Wistar-Kyoto rats, although Ang II blockade by cilazapril and E-4177 but not hydralazine significantly increased renal HGF mRNA in SHR-SP. Ang II blockade significantly increased renal HGF ( a protective growth factor for tubular epithelial cells ) ; thus, we examined tubular histological appearance
Reikvam et al., Expert Opin Investig Drugs 2010 (Leukemia, Myeloid, Acute) : The only significant effects of exogenous Ang-2 were decreased levels of HGF and endocan
Yokoyama et al., Ther Apher Dial 2010 : We investigated the following : ( i ) the expression of PPARgamma ; ( ii ) the effect of 15d-PGJ ( 2 ) on angiotensin II (Ang II) induced fibronectin ( FN ) expression and secretion ; ( iii ) the effect of 15d-PGJ ( 2 ) ( with or without Ang II and with or without the specific PPARgamma antagonist GW9662 ) and pioglitazone, a synthetic PPARgamma agonist, on hepatocyte growth factor (HGF) expression and secretion ; ( iv ) the effect of HGF on Ang II-induced FN expression and secretion ; ( v ) the expression of c-Met ( a specific HGF receptor ) and its phospho-signal ; and ( vi ) the involvement of HGF in the effect produced by 15d-PGJ ( 2 ) using selective c-Met inhibitor PHA-665752 ... We demonstrated the presence of c-Met, and presented evidence that HGF inhibits Ang II-induced FN expression and activates phosphorylation of c-Met, which is blocked by PHA-665752 ; 15d-PGJ ( 2 ) also activated c-Met phosphorylation