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CDH1 — PTGS2
Text-mined interactions from Literome
Noda et al., J Gastroenterol 2002
(Carcinoma...) :
These findings suggest that the
COX-2 inhibitor
affects the transcription of
E-cadherin , or that there may be some homeostatic link between the cell cycle and E-cadherin transcription
Dohadwala et al., Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
Cyclooxygenase-2 dependent regulation of
E-cadherin : prostaglandin E ( 2 ) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer ...
Cyclooxygenase-2 dependent regulation of
E-cadherin : prostaglandin E ( 2 ) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer ... These findings indicate that PGE ( 2 ), in autocrine or paracrine fashion, modulates transcriptional repressors of E-cadherin and thereby regulates
COX-2 dependent
E-cadherin expression in NSCLC
Jang et al., Yonsei Med J 2009
(Colonic Neoplasms) :
Ectopic expression of
COX-2 or Snail
reduced E-cadherin and induced a scattered, flattened phenotype with few intercellular contacts in colon cancer cells ... The expressions of
COX-2 and Snail
increased in areas with abnormal
E-cadherin expression
Choudhary et al., Neoplasia (New York, N.Y.) 2010
(Adenocarcinoma...) :
We have demonstrated that activation of PPARgamma promotes epithelial differentiation of NSCLC by increasing expression of
E-cadherin , as well as
inhibiting expression of
COX-2 and nuclear factor-kappaB ... We have demonstrated that activation of PPARgamma promotes epithelial differentiation of NSCLC by increasing expression of
E-cadherin , as well as
inhibiting expression of
COX-2 and nuclear factor-kappaB
Chen et al., Int J Mol Med 2013
(Stomach Neoplasms) :
COX-2 regulates
E-cadherin expression through the NF-?B/Snail signaling pathway in gastric cancer ... However, the molecular mechanisms through which
COX-2 regulates
E-cadherin expression and function have not yet been fully elucidated ... The aim of this study was to investigate the possible molecular mechanisms through which
COX-2 regulates
E-cadherin expression in gastric cancer