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CXCL12 — PARP1

Text-mined interactions from Literome

Katagiri et al., J Biol Chem 2004 : In Jurkat T cells, TCR cross linking triggered persistent Rap1 activation, and SDF-1 ( CXCL12 ) activated Rap1 transiently
Kanemitsu et al., Blood 2005 : In vitro, CXCL13 activated the small guanosine triphosphatase ( GTPase ) Rap1 in B cells, and corroborating this observation, a deficiency of RAPL, the Rap1 effector molecule, caused a significant reduction in shear-resistant B-cell adhesion to intercellular adhesion molecule 1 ( ICAM-1 )
Glodek et al., Leukemia 2007 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) : FAK-deficient REH cells also demonstrated reduced CXCL12 induced activation of the GTPase Rap1 , suggesting the importance of FAK in CXCL12 mediated integrin activation
Marković et al., PloS one 2013 : The roles of poly(ADP-ribose) polymerase-1 ( PARP-1 ) and transcription factor Yin Yang 1 (YY1) in Cxcl12 transcription were studied by examining their in vitro and in vivo binding affinities for the Cxcl12 promoter in a pancreatic beta cell line by the electrophoretic mobility shift assay and chromatin immunoprecipitation ... PARP-1 binding to the Cxcl12 promoter during basal and in STZ compromised conditions led us to conclude that PARP-1 regulates constitutive Cxcl12 expression