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CUL1 — STAT5A
Text-mined interactions from Literome
Boer et al., Exp Hematol 2003
:
STAT5 activation was examined in erythroid cell lines by analyzing the
effects of EPO and
SCF on
STAT5 tyrosine phosphorylation, serine phosphorylation, DNA binding, and STAT5 mediated gene transactivation ... SCF pretreatment followed by EPO stimulation resulted in a 9.0-fold+/-0.9-fold increase in STAT5 transactivation, while
SCF alone did not
increase STAT5 transactivation ...
SCF enhances the EPO mediated
STAT5 transactivation by triggering a PKA/CREB dependent pathway
Drayer et al., Stem Cells 2005
:
TPO stimulation of MO7e cells resulted in STAT5 transactivation, which could be enhanced 1.6-fold by costimulation with SCF, whereas
SCF alone did not
induce STAT5 transcriptional activity
Pallard et al., EMBO J 1995
(Leukemia, Megakaryoblastic, Acute) :
In contrast, neither interferon (IFN)-gamma nor the mitogenic
stem cell factor (SCF) activated
STAT5 , although IFN-gamma did activate STAT1 in those cells
Ryan et al., Exp Hematol 1997
:
These data indicate that
SCF stimulation of Kit
leads to activation of
STAT-5 DNA binding with kinetics distinct from Epo mediated stimulation