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IRF6 — NQO1

Text-mined interactions from Literome

Gharavi et al., J Pharm Sci 2007 (Carcinoma, Hepatocellular...) : Both TNF-alpha and LPS repressed the beta-naphthoflavone ( betaNF ) -mediated induction of Cyp1a1 and Nqo1 at mRNA and activity levels
Rushworth et al., J Immunol 2008 (Inflammation...) : Analysis of Nrf2 regulated gene expression in human monocytes showed that LPS induced the expression of the phase II detoxification gene NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) ... Furthermore, NQO1 mRNA or protein expression in response to LPS was regulated by Nrf2. Silencing Nrf2 expression in human monocytes inhibited LPS induced NQO1 expression ; however, in contrast, it significantly increased TNF and IL-1beta production ... These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis