Gene interactions and pathways from curated databases and text-mining

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ELAVL1 — IL10

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ELAVL1 → IL10 (decreases)
    Evidence: One manuscript describes the downregulation of HuR by IL-10 in monocytes [67], and attributes this as a major mechanism whereby IL-10 exerts systemic anti-inflammatory effects.

Text-mined interactions from Literome

Rajasingh et al., FASEB J 2006 (Carotid Artery Injuries) : IL-10 induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression ... IL-10 sensitivity to TNF depends on the ability of IL-10 to inhibit the expression and mRNA stabilizing protein HuR and via IL-10 mediated repression of p38 mitogen activated protein ( MAP ) kinase activation
Krishnamurthy et al., Circ Res 2009 (Disease Models, Animal...) : These changes were associated with IL-10 mediated inhibition of p38 mitogen activated protein kinase activation and repression of the cytokine mRNA stabilizing protein HuR