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IL7 — JAK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Fleming et al., J Immunol 2004
:
Cell lines derived from CD45-deficient animals experience prolonged
JAK/STAT activation in
response to
IL-7 stimulation, and constitutively elevated levels of phosphorylated src kinases
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Barata et al., Leukemia & lymphoma 2005
(Leukemia-Lymphoma, Adult T-Cell) :
IL-7 induces the activation of
Jak/STAT , MEK/Erk and PI3K/Akt signaling pathways in T-ALL cells
Tamarit et al., J Biol Chem 2013
:
We show that lipid raft inhibitors delay and reduce
IL-7 induced
JAK1 and JAK3 phosphorylation
Foxwell et al., Eur J Immunol 1995
:
Interleukin-7 can
induce the activation of
Jak 1 , Jak 3 and STAT 5 proteins in murine T cells
Tortolani et al., J Immunol 1995
(Leukemia) :
In addition, IL-4 and
IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and IL-4
activated both JAK3 and
JAK1 phosphotransferase activity
Sharfe et al., Blood 1995
:
Specific inhibition of
IL-7 induced
Jak kinase activity ablates p85 tyrosine phosphorylation, subsequent P13 kinase activation, and, ultimately, proliferation
Russell et al., Science 1994
(Severe Combined Immunodeficiency) :
IL-2, IL-4,
IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c )
induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases
Jak1 and Jak3