◀ Back to EPHB2
EPHB2 — IQGAP1
Text-mined interactions from Literome
Roy et al., Mol Cell Biol 2005
(MAP Kinase Signaling System) :
Similarly,
ERK1 promoted MEK binding to
IQGAP1 , but either MEK protein altered the association between IQGAP1 and ERK ... In addition, both knockdown and overexpression of
IQGAP1 reduced EGF stimulated activation of MEK and
ERK
Ren et al., Proc Natl Acad Sci U S A 2007
:
We previously documented that
IQGAP1 binds ERK and MAPK kinase ( MEK ) and
regulates EGF stimulated MEK and
ERK activity
Nojima et al., Nat Cell Biol 2008
(MAP Kinase Signaling System) :
Thus,
IQGAP3 is necessary and sufficient for driving cell proliferation and
ERK acts downstream of IQGAP3
Casar et al., Mol Cell Biol 2009
:
To phosphorylate the EGFr,
ERK1/2 activated at lipid rafts require the participation of
IQGAP1
Sbroggiò et al., Cardiovasc Res 2011
(Disease Models, Animal...) :
IQGAP1 regulates
ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload