Wang et al., J Biol Chem 2002
:
We show that RanBPM can induce GTP-Ras association and Erk phosphorylation and elevate serum response element-luciferase ( SRE-LUC ) expression, indicating that RanBPM can activate the Ras-Erk-SRE pathway
Johnson et al., Biochem Biophys Res Commun 2006
:
Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts
Atabakhsh et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
Transient and stable down-regulation of RanBPM stimulated ERK phosphorylation, leading to Bcl-2 up-regulation, while re-expression of RanBPM reversed these effects ... RanBPM was found to inhibit MEK and ERK activation induced by ectopic expression of active RasV12 ... Activation of ERK by active c-Raf was also prevented by RanBPM