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ILK — NOS2
Text-mined interactions from Literome
Tan et al., J Biol Chem 2002
:
Inhibition of
ILK activity by dominant negative ILK or a highly selective small molecule ILK inhibitor, in epithelial cells or LPS stimulated J774 cells and murine macrophages,
resulted in inhibition of
iNOS expression and NO synthesis ... Similarly,
ILK inhibition
suppressed the LPS stimulated
iNOS promoter activity ... Mutation of the NF-kappaB sites in the iNOS promoter abolished LPS- and
ILK mediated
regulation of
iNOS promoter activity ... We conclude that
ILK can
regulate NO production in macrophages by regulating
iNOS expression through a pathway involving PKB/Akt and NF-kappaB
Tsou et al., J Cell Biochem 2010
:
TNF-alpha mediated
iNOS expression was
attenuated by
integrin linked kinase (ILK) inhibitor ( KP392 ) and siRNA