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PTEN — SMAD3
Text-mined interactions from Literome
Hjelmeland et al., Cancer Res 2005
(Neoplasm Invasiveness) :
RNA interference ( RNAi ) suppression of
PTEN expression
enhances SMAD3 transcriptional activity and TGF-beta mediated induction of SMAD3 target genes whereas reconstitution of PTEN in a null cancer cell line represses the expression of TGF-beta regulated target genes
Mathieu et al., Mol Cell Neurosci 2008
:
Silencing Smad5 with siRNA or treatment with Noggin, a BMP antagonist, demonstrated that upregulation of
PTEN in NSPCs
required BMP/Smad signaling and that this pathway regulated cell cycle exit of NSPCs