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DPP6 — SMAD1
Text-mined interactions from Literome
Nakayama et al., Cell Mol Life Sci 2000
:
Binding of BMP-4 or
Dpp to its cognate receptor
leads to phosphorylation of intracellular signal transducing
Smad proteins that then form hetero-oligomers, translocate to the nucleus and modulate transcription of target genes
Torres-Vazquez et al., Dev Biol 2000
:
Previous work has shown that transcription of
Dpp-responsive genes
requires the activity of the BMP-specific
Smad , Mothers against dpp ( Mad )
Eapen et al., J Biol Chem 2013
(Calcium Signaling) :
Inhibition of store Ca ( 2+ ) depletion by 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetrakis ( acetoxymethyl ester ) or down-regulation of CaMKII by KN-62, a selective cell-permeable pharmacological inhibitor or a dominant negative plasmid of CaMKII, blocked
DPP mediated
Smad1 phosphorylation