Gene interactions and pathways from curated databases and text-mining

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DPP6 — SMAD1

Text-mined interactions from Literome

Nakayama et al., Cell Mol Life Sci 2000 : Binding of BMP-4 or Dpp to its cognate receptor leads to phosphorylation of intracellular signal transducing Smad proteins that then form hetero-oligomers, translocate to the nucleus and modulate transcription of target genes
Torres-Vazquez et al., Dev Biol 2000 : Previous work has shown that transcription of Dpp-responsive genes requires the activity of the BMP-specific Smad , Mothers against dpp ( Mad )
Eapen et al., J Biol Chem 2013 (Calcium Signaling) : Inhibition of store Ca ( 2+ ) depletion by 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetrakis ( acetoxymethyl ester ) or down-regulation of CaMKII by KN-62, a selective cell-permeable pharmacological inhibitor or a dominant negative plasmid of CaMKII, blocked DPP mediated Smad1 phosphorylation