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IL6 — SP1

Text-mined interactions from Literome

Borgatti et al., Biochem Biophys Res Commun 2007 (Cystic Fibrosis) : We report in this paper that : ( a ) IL-8, IL-6, IL-1beta, ICAM-1, and GRO-gamma genes are upregulated following infection of CF bronchial epithelial IB3-1 cells with P. aeruginosa ; ( b ) Sp1 transcription factor activity is induced following infection of the cystic fibrosis IB3-1 and CuFi-1 cell lines ; ( c ) inhibition of Sp1 activity using transcription factor decoy molecules leads to inhibition of the expression of IL-6 gene
Porée et al., J Biol Chem 2008 (Osteoarthritis) : Indeed, IL-6 and/or sIL-6R inhibit Sp1 and Sp3 expression and their binding activity to the 63-bp promoter
Canaff et al., J Biol Chem 2008 : A series of transfection P2 promoter-reporter analyses showed that Sp1 together with Stat1/3 was critical for IL-6 responsiveness of P2
Sancéau et al., J Biol Chem 1995 : Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors
Kang et al., J Biol Chem 1996 : Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor ... In this study we demonstrate that the transcription factor Sp1 binds to these repeats and plays an important role in basal and in inducible expression of the murine interleukin-6 gene
Cantwell et al., Mol Cell Biol 1998 (Acute-Phase Reaction) : Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1