Motomura et al., Gut 2006
(Fibrosis) :
These findings suggest that MCP-1 can induce fibrosis in the gut and that this process involves interaction between T cells and vimentin positive fibroblasts/myofibroblasts, as well as the subsequent upregulation of TGF-beta and TIMP-1 production
Jung et al., Cytotherapy 2011
:
In addition, the levels of monocyte chemoattractant protein-1 ( MCP-1 ) and tumor necrosis factor-a (TNF-a) were decreased, and tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) and vascular endothelial growth factor ( VEGF ) levels were increased at 4 weeks in both the IM-C and IM-I groups