Pastorino et al., J Biol Chem 1999
:
BAD phosphorylation by TNF was dependent on phosphatidylinositide-3-OH kinase (PI3K) and was accompanied by the translocation of BAD from the mitochondria to the cytosol
Uchida et al., Mol Cell Biol 2000
:
IRS-4 also promoted the activation of PKB/Akt and BAD phosphorylation during insulin stimulation ; however, it weakly bound or activated p85 associated PI 3-kinase and failed to mediate the activation of p70 ( s6k )
Wan et al., Int J Oncol 2001
:
Inhibitors of EGFR and PI 3-kinase blocked UV-induced phosphorylation of BAD , suggesting that EGFR mediates UV-activated cell survival pathway
Hila et al., Glia 2001
(Polyradiculoneuropathy) :
Sublytic C5b-9 stimulated Schwann cell survival through PI 3-kinase mediated phosphorylation of BAD ... PI-3 kinase-Akt pathway activation by C5b-9 induced, within 15 min, a 6.34 +/- 1.2-fold increase in BAD phosphorylation at Ser 136, but not at Ser 112