Gene interactions and pathways from curated databases and text-mining

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CA2 — GAST

Text-mined interactions from Literome

Lindström et al., J Physiol 2001 (Calcium Signaling) : 2. In the presence of 2 mM extracellular Ca2+ , gastrin and PACAP induced secretion and raised [ Ca2+ ] i
Xiao et al., Am J Physiol Regul Integr Comp Physiol 2004 : Gastrin from 10 ( -12 ) to 10 ( -6 ) M did not stimulate amylase secretion nor did it ( 100 nM ) induce [Ca2+ ] i increase
Shinohara et al., Brain Res 1992 : Gastrin-I and CCK-4 also significantly attenuated the increases in [Ca2+ ] i induced by glutamate
Olszewska-Pazdrak et al., J Biol Chem 2004 : Epidermal growth factor potentiates cholecystokinin/gastrin receptor mediated Ca2+ release by activation of mitogen activated protein kinases ... G17 activation of the cholecystokinin/gastrin receptor ( CCK ( 2 ) R ), a G protein coupled receptor, stimulates release of Ca2+ from inositol 1,4,5-triphosphate-sensitive Ca2+ stores
Cabero et al., Biochem Biophys Res Commun 1992 : Effects of gastrin on cytosolic free Ca2+ in individual, acid secreting rat parietal cells ... The effects of gastrin on cytosolic free Ca2+ ( [ Ca2+ ] i ) in single, isolated rat gastric parietal cells were investigated using the fluorescent probe Fura-2 and digital image analysis
Sui et al., Zhong Yao Cai 2005 (Stomach Ulcer) : Dangshen containing serum can inhibit the intracellular [Ca2+ ] i increase induced by gastrin in a dose dependent manner and it may be one of the mechanisms of its reduction on acid secretion which has a close relation with the formation of ulcerous diseases
Grossini et al., J Mol Endocrinol 2013 : As eNOS is the Ca(2) ( + ) -dependent isoform of the enzyme, we aimed to examine the effects of gastrin-17 on Ca(2) ( + ) movements
Tsunoda et al., FEBS Lett 1987 : In the isolated parietal cell the following observations were made : gastrin led to an increase in cytoplasmic free Ca2+ concentration ([Ca2+]i) even in the absence of medium Ca2+ and to transient membrane depolarization in both the absence of the medium Ca2+ and the fura-2 loaded cell
Tsunoda et al., Biochim Biophys Acta 1986 : Gastrin induces intracellular Ca2+ release and acid secretion regulation by the microtubular-microfilamentous system ... The results suggest that the microtubular-microfilamentous system regulates gastrin induced intracellular Ca2+ release and acid secretion
Shapiro et al., Endocrinology 1981 : Gastrin stimulated oxyntic cell carbonic anhydrase in the dose range of 2.3 X 10 ( -15 ) to 2.3 X 10 ( -11 ) M
Askew et al., Aust N Z J Surg 1981 : A cytochemical section bioassay has been used to assess the carbonic anhydrase activity, induced by the gastrin peptides G13, G17 and G34 ( concentration 5.0-0.005 pg/ml ), in guinea pig parietal cells
Todisco et al., J Biol Chem 1995 : While gastrin increased [Ca2+ ] i in AR4-2J cells, G-Gly had no effect
Kaise et al., J Biol Chem 1995 : Gastrin increased [Ca2+ ] i, although G-Gly did not, however, genistein ( a tyrosine kinase inhibitor ) significantly reduced induction of luciferase activity by both G-Gly and gastrin
Sethi et al., Cancer Res 1993 (Carcinoma, Small Cell...) : Accordingly, gastrin ( 1-100 nM ) did not cause any measurable increase in [ Ca2+ ] i
Roche et al., Biochem J 1993 : The mechanism whereby gastrin-type receptor and muscarinic M3-type receptor regulate free intracellular Ca2+ concentration ([Ca2+]i) was studied in rabbit gastric parietal cells stimulated by either gastrin or carbachol
Seensalu et al., J Clin Invest 1997 : Bombesin induced gastrin release from canine G cells is stimulated by Ca2+ but not by protein kinase C, and is enhanced by disruption of rho/cytoskeletal pathways ... Thus, it is concluded that bombesin induced gastrin release from canine G cells is stimulated by Ca2+ but not by PKC, and is enhanced by disruption of rho/cytoskeletal pathways
Squires et al., Am J Physiol 1999 (Calcium Signaling) : These data demonstrated that bombesin stimulated gastrin release from human antral G cells resulted from activation of GRPRs and involved both release of intracellular Ca2+ and influx of extracellular Ca2+ through a combination of L-type voltage gated and IP3 gated Ca2+ channels