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CA2 — GAST
Text-mined interactions from Literome
Lindström et al., J Physiol 2001
(Calcium Signaling) :
2. In the
presence of 2 mM extracellular
Ca2+ ,
gastrin and PACAP induced secretion and raised [ Ca2+ ] i
Xiao et al., Am J Physiol Regul Integr Comp Physiol 2004
:
Gastrin from 10 ( -12 ) to 10 ( -6 ) M did not
stimulate amylase secretion nor did it ( 100 nM ) induce
[Ca2+ ] i increase
Shinohara et al., Brain Res 1992
:
Gastrin-I and CCK-4 also significantly
attenuated the increases in
[Ca2+ ] i induced by glutamate
Olszewska-Pazdrak et al., J Biol Chem 2004
:
Epidermal growth factor potentiates
cholecystokinin/gastrin receptor
mediated Ca2+ release by activation of mitogen activated protein kinases ... G17 activation of the
cholecystokinin/gastrin receptor ( CCK ( 2 ) R ), a G protein coupled receptor,
stimulates release of
Ca2+ from inositol 1,4,5-triphosphate-sensitive Ca2+ stores
Cabero et al., Biochem Biophys Res Commun 1992
:
Effects of
gastrin on cytosolic free
Ca2+ in individual, acid secreting rat parietal cells ... The
effects of
gastrin on cytosolic free
Ca2+ ( [ Ca2+ ] i ) in single, isolated rat gastric parietal cells were investigated using the fluorescent probe Fura-2 and digital image analysis
Sui et al., Zhong Yao Cai 2005
(Stomach Ulcer) :
Dangshen containing serum can inhibit the intracellular
[Ca2+ ] i increase
induced by
gastrin in a dose dependent manner and it may be one of the mechanisms of its reduction on acid secretion which has a close relation with the formation of ulcerous diseases
Grossini et al., J Mol Endocrinol 2013
:
As eNOS is the Ca(2) ( + ) -dependent isoform of the enzyme, we aimed to examine the
effects of
gastrin-17 on
Ca(2) ( + ) movements
Tsunoda et al., FEBS Lett 1987
:
In the isolated parietal cell the following observations were made :
gastrin led to an increase in cytoplasmic free Ca2+ concentration ([Ca2+]i) even in the absence of medium
Ca2+ and to transient membrane depolarization in both the absence of the medium Ca2+ and the fura-2 loaded cell
Tsunoda et al., Biochim Biophys Acta 1986
:
Gastrin induces intracellular
Ca2+ release and acid secretion regulation by the microtubular-microfilamentous system ... The results suggest that the microtubular-microfilamentous system regulates
gastrin induced intracellular
Ca2+ release and acid secretion
Shapiro et al., Endocrinology 1981
:
Gastrin stimulated oxyntic cell
carbonic anhydrase in the dose range of 2.3 X 10 ( -15 ) to 2.3 X 10 ( -11 ) M
Askew et al., Aust N Z J Surg 1981
:
A cytochemical section bioassay has been used to assess the
carbonic anhydrase activity,
induced by the
gastrin peptides G13, G17 and G34 ( concentration 5.0-0.005 pg/ml ), in guinea pig parietal cells
Todisco et al., J Biol Chem 1995
:
While
gastrin increased
[Ca2+ ] i in AR4-2J cells, G-Gly had no effect
Kaise et al., J Biol Chem 1995
:
Gastrin increased
[Ca2+ ] i, although G-Gly did not, however, genistein ( a tyrosine kinase inhibitor ) significantly reduced induction of luciferase activity by both G-Gly and gastrin
Sethi et al., Cancer Res 1993
(Carcinoma, Small Cell...) :
Accordingly,
gastrin ( 1-100 nM ) did not
cause any measurable increase in [
Ca2+ ] i
Roche et al., Biochem J 1993
:
The mechanism whereby
gastrin-type receptor and muscarinic M3-type receptor
regulate free intracellular
Ca2+ concentration ([Ca2+]i) was studied in rabbit gastric parietal cells stimulated by either gastrin or carbachol
Seensalu et al., J Clin Invest 1997
:
Bombesin induced
gastrin release from canine G cells is
stimulated by
Ca2+ but not by protein kinase C, and is enhanced by disruption of rho/cytoskeletal pathways ... Thus, it is concluded that bombesin induced
gastrin release from canine G cells is
stimulated by
Ca2+ but not by PKC, and is enhanced by disruption of rho/cytoskeletal pathways
Squires et al., Am J Physiol 1999
(Calcium Signaling) :
These data demonstrated that bombesin stimulated
gastrin release from human antral G cells resulted from activation of GRPRs and
involved both release of intracellular
Ca2+ and influx of extracellular Ca2+ through a combination of L-type voltage gated and IP3 gated Ca2+ channels