◀ Back to IL4

IL4 — SOAT1

Text-mined interactions from Literome

Dickensheets et al., Proc Natl Acad Sci U S A 1999 (Translocation, Genetic) : IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 ( signal transducer and activator of transcription-6 )
Haque et al., J Biol Chem 2000 : We show that the SH2 domains of SOCS-2, SOCS-3, and cytokine-inducible SH2 containing protein are functionally redundant in regulating the IL-4 dependent Jak-Stat signaling ... Thus, the Thr-Phe motif in the Pre-SH2 domain plays a critical role in SOCS-3 mediated inhibition of the IL-4 dependent Jak-Stat signaling, likely by regulating the mode of SOCS-Jak interaction
Guiter et al., Blood 2004 (Lymphoma, B-Cell...) : IL-4 and IL-13 transcripts were absent in PMBL cell lines and expressed at low levels in tumors, indicating that, contrary to classical Hodgkin lymphoma ( cHL ), STAT6 activation is not due to an autocrine IL-4/IL-13 secretion
Bian et al., Proc Natl Acad Sci U S A 2005 : We now demonstrate that ( i ) an IL-4 receptor alpha-subunit ( IL-4Ralpha ) /Stat6 dependent but T cell independent pathway is the key for the nematode induced host NOS-2 inhibition ; ( ii ) endogenous IL-4 and IL-13, the only known IL-4Ralpha ligands, are not required for activating the pathway ; and ( iii ) treatment of RAW264.7 cells with parasite cultured medium inhibits NOS-2 expression but not cyclooxygenase 2 expression
Aoudjehane et al., FASEB J 2007 : We first measured IL-4 receptor expression, STAT6 activation by IL-4 , and STAT6 inhibition by an anti-IL-4 antibody or by STAT6 siRNA transfection
Liu et al., J Immunol 2007 : Activation of NF-kappaB, STAT6 , and STAT1 was induced in eosinophils by TNF-alpha, IL-4 , and IFN-gamma, respectively
Tanabe et al., Clin Exp Allergy 2008 (Hyperplasia) : In contrast, the IL-4 induced mucus production, mucus secretion and STAT activation were not inhibited by recombinant IL-13Ralpha(2)
Aoudjehane et al., Lab Invest 2008 : We first analyzed IL-4 receptor expression, STAT-6 activation by IL-4 , and STAT-6 inhibition by an anti-IL-4 antibody or by STAT-6 small interfering RNA ( siRNA ) transfection
Chiba et al., J Smooth Muscle Res 2009 (Asthma...) : In the present study, the effects of interleukin-13 (IL-13) and IL-4 on activation of these STAT molecules were examined in cultured human bronchial smooth muscle cells ( hBSMCs )
Goenka et al., Immunol Res 2011 : Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system
Seidel et al., Proc Natl Acad Sci U S A 1995 (Carcinoma, Hepatocellular...) : We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the STAT complexes activated by IFN-gamma, interleukin (IL) 6, granulocyte-macrophage colony stimulating factor, and IL-4 ... We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the STAT complexes activated by IFN-gamma, interleukin (IL) 6, granulocyte-macrophage colony stimulating factor, and IL-4 ... We show that ( i ) as suggested earlier, a core palindromic TT -- AA motif with a 5-bp spacing displays general STAT binding, ( ii ) a palindromic motif with a spacing of 4 bp selectively binds to complexes containing Stat3, and ( iii ) a motif with a 6-bp spacing selectively binds the STAT complexes activated by IL-4
Murata et al., J Immunol 1996 (Colonic Neoplasms) : Both IL-13 and IL-4 induced phosphorylation of IL-4 STAT ( STAT6 ) but not STAT1, STAT3, or STAT5
Ohmori et al., J Immunol 1997 : The effects of IFN-gamma and IL-4 on transcription of a reporter gene under control of a 1.3-kb fragment from the IRF-1 gene promoter or the STAT binding element (SBE) from this gene in the context of a heterologous promoter are similar to their effects on the endogenous IRF-1 gene