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IL4 — THY1
Text-mined interactions from Literome
Warner et al., J Immunol 1991
:
Pretreated B cells displayed unique phenotypic changes after treatment with anti-Ig, including a diminution of
Thy-1 expression in
response to LPS +
IL-4 , as well as a reduction in membrane IgM and J11d expression ( i.e., they were IgMlo, IgDmed, and J11dlo, as recently reported for anergic B cells in transgenic mice )
Snapper et al., J Immunol 1990
:
IL-4 induces
Thy-1 expression and IgE secretion by LPS -- and T cell stimulated murine B cells in vitro
Snapper et al., Cell Immunol 1990
:
IFN-gamma suppresses
IL-4 induced
Thy-1 expression by inhibiting the induction of steady-state levels of Thy-1-specific mRNA
Louie et al., Int Immunol 1995
:
Positive and negative
regulation of
Thy-1 expression on B lymphocytes by
IL-4 ... Expression of the
Thy-1 membrane antigen is generally confined to thymocytes and T lymphocytes, but its expression on B lymphocytes can be
induced by culture with the lymphokine
IL-4 ... The present study was designed to determine whether
IL-4 signaling
induces Thy-1 expression on all B lymphocytes, or whether this induction is dependent upon IL-4 mediated activation ...
IL-4 was
required for
Thy-1 expression in cells which were dependent upon IL-4 for continuous growth in culture but markedly decreased Thy-1 expression in cells which are growth inhibited by IL-4 ... In a mutant subclone of the latter cells in which IL-4 signaling does not cause growth inhibition,
IL-4 did not
affect Thy-1 expression ... The
regulation of
Thy-1 expression by
IL-4 is manifest at the level of Thy-1 mRNA