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STAT1 — TCF19
Text-mined interactions from Literome
Federico et al., Blood 2001
(Acquired Immunodeficiency Syndrome) :
Nef dependent STAT1 activation is followed by increased expression of both STAT1 and interferon regulatory factor-1, a
transcription factor transcriptionally
regulated by
STAT1 activation
Ghoreschi et al., J Mol Med (Berl) 2003
(Psoriasis) :
STAT1 activation by IFN-gamma is
followed by T-bet activation, a master
transcription factor for Th1 lymphocytes
Plumlee et al., Virology journal 2005
:
Phosphorylation of
Stat1 on a conserved serine amino acid at position 727 ( S727 ),
results in maximal transcriptional activity of the ISGF-3
transcription factor complex 15
Torrero et al., Cancer Res 2006
(Carcinoma, Squamous Cell) :
Signal transducer and activator of transcription 1 ( Stat1 ) is considered a key
transcription factor that inhibits tumorigenesis, and
Stat1 activation in the host is
required for interleukin-12 (IL-12) mediated generation of CTL activity
Rani et al., J Interferon Cytokine Res 2007
:
TRAIL was not
induced by IFN-beta in mutant cell lines U2A, U3A, U4A, U5A, and U6A, which lack, respectively, IFN regulatory factor-9 (IRF-9),
Stat1 , Jak1, IFNAR-2.2, and Stat2, indicating
transcription factor IFN stimulated gene factor 3 ( ISGF3 ) was essential for the induction of this gene
Cantrell et al., Immunobiology 2010
(Melanoma, Experimental) :
Activation of both cell types is associated with the induction of the MAP kinase pathway, the phosphorylation of
STAT1 , STAT5 and AKT and with
transcription factor NF-kappaB
activation in vitro and in vivo