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CRY2 — TIMELESS

Pathways - manually collected, often from reviews:

• NCI Pathway Database Circadian rhythm pathway: PER1-2 / CRY1-2 complex (PER1_PER2-CRY2_CRY1) → PER1/TIMELESS complex (TIMELESS-PER1) (modification, activates)
  
• NCI Pathway Database Circadian rhythm pathway: TIMELESS (TIMELESS) → CRY2 (CRY2) (modification, collaborate) Unsal-Kaçmaz et al., Mol Cell Biol 2005*
• NCI Pathway Database Circadian rhythm pathway: TIMELESS (TIMELESS) → TIMELESS/CRY2 complex (CRY2-TIMELESS) (modification, collaborate)
  Unsal-Kaçmaz et al., Mol Cell Biol 2005*
• NCI Pathway Database Circadian rhythm pathway: CRY2 (CRY2) → TIMELESS/CRY2 complex (CRY2-TIMELESS) (modification, collaborate)
  Unsal-Kaçmaz et al., Mol Cell Biol 2005*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRY2 — TIMELESS (physical association, affinity chromatography technology) Unsal-Kaçmaz et al., Mol Cell Biol 2005*
• IRef Hprd Interaction: CRY2 — TIMELESS (in vivo) Unsal-Kaçmaz et al., Mol Cell Biol 2005*
• IRef Intact Interaction: CRY2 — TIMELESS (physical association, anti tag coimmunoprecipitation) Unsal-Kaçmaz et al., Mol Cell Biol 2005*

Text-mined interactions from Literome

Peschel et al., Proc Natl Acad Sci U S A 2006 : In Drosophila melanogaster, the circadian clock is synchronized with the natural environment by light dependent degradation of the clock protein Timeless , mediated by the blue-light photoreceptor Cryptochrome ( Cry )
Peschel et al., Curr Biol 2009 : In Drosophila, the blue-light photoreceptor Cryptochrome ( Cry ) mediates a rapid light dependent degradation of the clock protein Timeless ( Tim ) via the F box protein Jetlag ( Jet ) and the proteasome, which initiates the resetting of the molecular clock [ 2, 3 ]