Gene interactions and pathways from curated databases and text-mining

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EGF — RPS6KA2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RPS6KA2 → EGF (increases, EGF Activity) Xing et al., Mol Cell Biol 1998*
    Evidence: The expression of RSK1, RSK2, or RSK3 in COS cells substantially increased the level of EGF-induced Gal4CREB Ser- 133 phosphorylation (Fig. 2B). Thus, all three RSK family members appear to be activated and able to phosphorylate CREB Ser-133 in cells upon growth factor stimulation.