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ITGAV — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of F2-ITGAV-ITGB3 → VEGFA (increases)
  Evidence: Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fol...
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → VEGFA (increases, VEGFA Activity)
  Evidence: VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenovirus gene transfer mediated by alphavbeta3 and also activated other integrins, alphavbeta5, alpha5beta1, and alpha2beta1, involved in angiogenesis. The major findings of our studies are as follows. First, VEGF165 can activate integrin aVb3, leading to enhanced adhesion of endothelial cells to a variety of ligands.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → VEGFA (increases)
  Evidence: VPF/VEGF induced dermal microvascular EC expression of mRNAs encoding the alphav and beta3 integrin subunits resulting in increased levels of the alphavbeta3 heterodimer at the cell surface,
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3-VTN → VEGFA (increases)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB5 → VEGFA (increases, VEGFA Activity)
  Evidence: VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenovirus gene transfer mediated by alphavbeta3 and also activated other integrins, alphavbeta5, alpha5beta1, and alpha2beta1, involved in angiogenesis. The major findings of our studies are as follows. First, VEGF165 can activate integrin aVb3, leading to enhanced adhesion of endothelial cells to a variety of ligands.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB5 → VEGFA (increases, VEGFA Activity)
  Evidence: Fifth, VEGF165 activation is not targeted to a single integrin; b1 integrins, as exemplified by a5b1 and a2b1, also are affected by VEGF165 stimulation. In addition, our data suggest that aVb5 can be activated by the growth factor.
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: Hsp90 (HSP90AA1) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → Src (SRC) (modification, activates) Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → PYK2 (PTK2B) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay
• NCI Pathway Database Integrins in angiogenesis: Hsp90 (HSP90AA1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: ROCK (ROCK1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → RhoA (RHOA) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: None → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: RHOA/GDP complex (RHOA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → FAK (PTK2) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Le Boeuf et al., Mol Biol Cell 2006
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., Mol Biol Cell 2006
• NCI Pathway Database Integrins in angiogenesis: VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., Mol Biol Cell 2006
• Reactome Reaction: ITGAV → VEGFA (indirect_complex) Masson-Gadais et al., Cell Stress Chaperones 2003, Mahabeleshwar et al., J Exp Med 2006*, Somanath et al., Angiogenesis 2009*
• Reactome Reaction: ITGAV → VEGFA (reaction) Masson-Gadais et al., Cell Stress Chaperones 2003, Butler et al., J Biol Chem 2005, Le Boeuf et al., Mol Biol Cell 2006, Mahabeleshwar et al., J Exp Med 2006*, Somanath et al., Angiogenesis 2009*

Text-mined interactions from Literome

Fukushima et al., Biol Reprod 2005 : VEGF induced expression of ITGAV/ITGB3 subunits and protein aggregation, as in the case of TNF, which in turn, induces synthesis of VEGF in TCL1 cells
Suzuma et al., Invest Ophthalmol Vis Sci 1998 : VEGF ( 25 ng/ml ) increased integrin alphav , beta3, and 35 mRNA after 24 hours 6.1+/-0.8-fold ( P < 0.001 ), 5.9+/-1.1-fold ( P < 0.001 ), and 1.9+/-0.2-fold ( P < 0.01 ), respectively ... Induction of integrin alphav by VEGF and hypoxia was confirmed in the protein level