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HRAS — STAT3

Text-mined interactions from Literome

Yeh et al., DNA Cell Biol 2009 (Cell Transformation, Neoplastic...) : Interleukin-6 (IL-6) induced phosphorylation of tyrosine-705 and serine-727, as well as DNA binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression ... We demonstrate that Ha-ras and Stat3 acting together synergistically induce Stat3 phosphorylation at serine-727 phosphorylation and cyclin D1 expression and further enhance transformation and tumorigenicity of the cell ... Ha-ras induced Stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin D1 and suppression of cell apoptosis ... The effect of Ha-ras on Stat3 phosphorylation at serine-727 was also detected in human bladder ( T24 ) and lung ( H460 ) cancer cells
Coffer et al., Oncogene 1997 : Utilising a dominant negative mutant of p21ras we demonstrate that both insulin induced Stat3 DNA binding and also transactivation do not require p21ras