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TAB1 — XIAP
Pathways - manually collected, often from reviews:
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NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TAK1/XIAP complex (MAP3K7-XIAP)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
XIAP (XIAP)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
Evidence: mutant phenotype, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
TAB1
—
XIAP
Yamaguchi et al., EMBO J 1999
-
IRef Bind_translation Interaction:
TAB1
—
XIAP
(coimmunoprecipitation)
Yamaguchi et al., EMBO J 1999
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IRef Bind_translation Interaction:
TAB1
—
XIAP
(two hybrid)
Yamaguchi et al., EMBO J 1999
-
IRef Biogrid Interaction:
XIAP
—
TAB1
(physical association, affinity chromatography technology)
Sanna et al., Mol Cell Biol 2002*
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IRef Biogrid Interaction:
XIAP
—
TAB1
(direct interaction, two hybrid)
Yamaguchi et al., EMBO J 1999
-
IRef Biogrid Interaction:
XIAP
—
TAB1
(physical association, affinity chromatography technology)
Yamaguchi et al., EMBO J 1999
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IRef Biogrid Interaction:
XIAP
—
TAB1
(physical association, affinity chromatography technology)
Sanna et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
XIAP
—
TAB1
(in vivo)
Yamaguchi et al., EMBO J 1999
-
IRef Ophid Interaction:
TAB1
—
XIAP
(aggregation, confirmational text mining)
Yamaguchi et al., EMBO J 1999
-
IRef Ophid Interaction:
TAB1
—
XIAP
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sanna et al., J Biol Chem 2002
:
The expression of a catalytically inactive mutant of
TAK1 blocked
XIAP/ILPIP synergistic activation of JNK1 thereby implicating TAK1 in this signaling pathway
Jin et al., Cancer Res 2009
(MAP Kinase Signaling System) :
XIAP mediates activation of the upstream IKK kinase,
TAK1 , and couples activated TAK1 to the IKK complex