◀ Back to TGFB1
CDK4 — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pillaire et al., Exp Eye Res 1999
:
TGFbeta1 induces an up-regulation of the CDK inhibitor p15(INK4B)with its subsequent association to CDK4, and a decline in
CDK4 protein level
Coulonval et al., Exp Cell Res 2003
:
In the presence of TSH,
transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4, but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27, not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to p27, but also by
inhibiting CDK4 phosphorylation within residual p27 bound cyclin D3-CDK4 complexes
Shi et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004
:
Western blot method was used to examine
effect of
TGF-beta1 on expression of cyclin A, Cyclin D1, CDK2 and
CDK4 in G1 phase of cell cycle ... ( 2 ) 2 ng/ml
TGF-beta1 could significantly
inhibit the production of cyclin A, cyclin D1, CDK2 and
CDK4 , the protein levels were significantly lower than control group
Yang et al., Biol Reprod 2006
:
EGF and
TGFB1 together
inhibited CDK4 activation and DNA synthesis
Chen et al., Molecular vision 2006
:
To evaluate the
role of
cyclin dependent kinase inhibitors p57 and p15 in
transforming growth factor (TGF)-beta1 or TGF-beta2 inhibited proliferation of primary cultured human limbal epithelial cells using short interfering RNA ( siRNA )
Ko et al., Oncogene 1995
:
In mink lung epithelial cells,
TGF-beta 1 inhibits
Cdk4 expression
Kleeff et al., J Biol Chem 1998
(Pancreatic Neoplasms) :
TGF-beta1 caused a delayed but sustained increase in the protein levels of the
cyclin dependent kinase inhibitors p15(Ink4B), p21 ( Cip1 ), and p27 ( Kip1 ) and a sustained increase in type I and II TGF-beta receptors ( TbetaRI and TbetaRII ) mRNA and protein levels
Quesnel et al., Blood 1998
(Myelodysplastic Syndromes) :
p15(INK4b) gene is an inhibitor of cyclin dependent kinase
(CDK) 4 and CDK6 whose expression is
induced by
transforming growth factor ( TGF ) beta
Kamesaki et al., J Immunol 1998
(Lymphoma, B-Cell) :
In contrast to epithelial cells, however,
TGF-beta1 had little or no effect on the
Cdk4 and p21WAF1/Cip1 protein levels in these B cells
Parekh et al., Cell Growth Differ 1998
:
Both
TGF-beta1 and type V collagen
inhibited retinoblastoma protein phosphorylation and the expression of
cyclin dependent kinase (cdk) 4 and cdk2, but not p27Kip expression