Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — FGFR3

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)

Text-mined interactions from Literome

Winter et al., Oncogene 2007 : Reporter assays confirmed that the Ang-2 promoter was regulated by FGFR1 signaling and a small molecule inhibitor of FGFR activity, PD173074, could abrogate this response
Kawada et al., Am J Physiol Heart Circ Physiol 2007 : In contrast, in a group with local administration of losartan ( 10 mM, n = 6 ) through the dialysis probe, ANG II inhibited the stimulation induced ACh release ( 8.0 +/- 0.8 vs. 5.8 +/- 1.0 nM, P < 0.05 )
Tota et al., Psychopharmacologia 2013 (Synaptic Transmission) : This study suggests that Ang II , via the AT1 receptor, affects spatial memory formation, CBF, and ACh level while AT2 receptor has no significant role