Tiraby et al., J Biol Chem 2003
(Obesity) :
Peroxisome proliferator activated receptor gamma ( PPAR gamma ) and PPAR gamma coactivator 1 alpha ( PGC-1 alpha ) activate mouse UCP1 gene transcription ... We show here that human PGC-1 alpha induced the activation of the human UCP1 promoter by PPAR gamma ... The PPAR gamma agonist rosiglitazone potentiated the effect of PGC-1 alpha on UCP1 expression and fatty acid oxidation
Kang et al., Mol Cell Biol 2005
:
Although enforced expression of these adipogenic transcription factors restores lipid accumulation and expression of FABP4 in Wnt expressing cells, additional expression of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1) Lomax et al., Endocrinology 2007
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These data are consistent with a model in which postnatal loss of UCP1 expression and beta-adrenergic induction of the brown adipocyte phenotype is due to loss of expression of PGC-1alpha and PPARalpha